Plasmodium falciparum chloroquine resistance

Discussion in 'Canada Drug' started by Sento, 05-Mar-2020.

  1. qazex XenForo Moderator

    Plasmodium falciparum chloroquine resistance


    Rapid diagnostic assays for Pf CRT mutations are already employed as surveillance tools for drug resistance. Here, we review recent field studies that support the central role of Pf CRT mutations in chloroquine resistance.

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    Malaria. Chloroquine has long been used in the treatment or prevention of malaria from Plasmodium vivax, P. ovale, and P. malariae, excluding the malaria parasite Plasmodium falciparum, for it started to develop widespread resistance to it. Chloroquine has been extensively used in mass drug administrations, which may have contributed to the emergence and spread of resistance. Plasmodium falciparum resistance to anti-malarial drugs remains a major obstacle to malaria control and elimination. The parasite has developed resistance to every anti-malarial drug introduced for wide-scale treatment. However, the spread of resistance may be reversible. Plasmodium falciparum chloroquine resistance is a major cause of worldwide increases in malaria mortality and morbidity. Recent laboratory and clinical studies have associated chloroquine.

    Recognition of the value of chloroquine was delayed, and it was not brought forward until it was reevaluated in the United States and designated the drug of choice against malaria near the end of World War II [3]. These studies suggest chloroquine resistance arose in ⩾4 distinct geographic foci and substantiate an important role of immunity in the outcomes of resistant infections after chloroquine treatment. Investigation of the resistance mechanisms and of the role of immunity in therapeutic outcomes will support new approaches to drugs that can take the place of chloroquine or augment its efficiency Early in the 20th century, intense demands for an effective quinine substitute launched the discovery and evaluation of a series of organic compounds (beginning with methylene blue), which led to pamaquine and quinacrine after World War I and ultimately produced chloroquine in 1934 [1, 2].

    Plasmodium falciparum chloroquine resistance

    Chloroquine-Resistant Malaria The Journal of Infectious., The return of chloroquine-susceptible Plasmodium falciparum.

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  4. Update Chloroquine-Resistant Plasmodium falciparum -- Africa. The first confirmed cases of chloroquine-resistant Plasmodium falciparum acquired in Africa were reported in 1978 1 and occurred in non-immune travelers who had been in East Africa for relatively short periods of time.

    • Update Chloroquine-Resistant Plasmodium falciparum -- Africa.
    • Chloroquine Resistance in Plasmodium falciparum Malaria Parasites..
    • Efflux of chloroquine from Plasmodium falciparum mechanism..

    Nov 27, 2019 Juge, N. et al. Plasmodium falciparum chloroquine resistance transporter is a H + -coupled polyspecific nutrient and drug exporter. Chloroquine mechanism of drug action and resistance in Plasmodium falciparum. Slater AF1. Author information 1Picower Institute for Medical Research, Manhasset, NY 11030. Quinoline-containing drugs such as chloroquine and quinine have had a long and successful history in antimalarial chemotherapy. Increased resistance by Plasmodium falciparum parasites led to the withdrawal of the antimalarial drugs chloroquine and sulphadoxine-pyrimethamine in Ethiopia. Since 2004 artemether-lumefantrine has served to treat uncomplicated P. falciparum malaria.

     
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  6. olegish Moderator

    Plaquenil is the brand name for the prescription drug hydroxychloroquine. How Lupus Affects the Muscles, Tendons and Joints Lupus. Muscle Weakness in thighs DailyStrength Hydroxychloroquine - thigh muscle weakness?
     
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  8. stefan XenForo Moderator

    Plaquenil Side Effects on Your Eyes and Vision Plaquenil hydroxychloroquine is in a class of drugs called disease-modifying anti-rheumatic drugs, which are used to decrease inflammation, pain and joint damage. While today it is used to treat autoimmune conditions, such as rheumatoid arthritis and lupus, it was originally used as an anti-malaria drug.

    Plaquenil Hydroxychloroquine - Side Effects, Dosage.