These, as well as other commonly used medications, can cause various types of allergic reactions that frequently lead to hyperpigmentation (dark patches). There are four primary types of medication reactions that can lead to often troubling and disfiguring hyperpigmentation: A fixed drug eruption is a round, dark patch or eruption that results from a reaction to a drug (usually a prescription medication). Drug of choice for chloroquine resistant malaria Chloroquine proguanil dose Cheap aralen lupus Is chloroquine available over the counter I think it's due to Hydroxycholoroquine-induced hyperpigmentation an example of drug-induced skin pigmentation. I thought it worth showing those of you on the medication. Why is it so much worse on the right forearm? Well she's only just started to drive again. Home August 2013 - Volume 19 - Issue 5 Hydroxychloroquine-Induced Hyperpigmentation. Log in to view full text. If you're not a subscriber, you can A thorough history is essential to determine the cause of a pigmentary disorder. Very important information to gather during the evaluation of the patient includes the temporal relationship of medications taken and the development of the pigmentation, the presence of accentuation from exposure to sunlight, a list of medications taken, and a personal and family history of disorders such as. The round patch is usually fixed to one spot will appear in this same location within 24 hours of each dose taken. This type of reaction leaves a grey-blue, round patch on the skin. Hydroxychloroquine skin pigmentation Will you have Skin hyperpigmentation with Plaquenil - eHealthMe, Hydroxychloroquine-Induced Hyperpigmentation JCR Journal. Plaquenil avisPlaquenil sarcoidosis treatmentAct chloroquine and arte sunate Skin figure 1A,B. There was no pigmentation at other body sites. Biopsy from the plaque showed necrobiotic collagen with intradermal mucin and perivascular lymphohistiocytic infiltrate accom-panied by brown coarse pigment in the dermis figure 1C,D. The pigment was negative on Perl’s stain figure 1E. This was a unique pattern of Hydroxychloroquine induced cutaneous pigmentation a unique.. Drug-Induced Pigmentation Clinical Presentation History.. Hydroxychloroquine Oral Uses, Side Effects, Interactions.. Hydroxychloroquine is a well-tolerated medication for various rheumatologic and dermatologic conditions. Its main side effects are gastrointestinal upset, skin rash, headache, and ocular toxicity1. Within the eye, hydroxychloroquine can adversely impact the cornea, ciliary body, and retina1 Brown Skin Home / Skin / Pigmentation / Drug-Induced Pigmentation. Skin Drug-Induced Pigmentation. Women with brown skin, particularly those of African and Latino descent, have a high incidence of hypertension, diabetes and heart disease and consequently take medications for those medical problems. Hydroxychloroquine is an antimalarial medication that can cause hyperpigmentation of nails, mucosa, and skin 1–5. Retrospective studies cite the incidence of drug-related hyperpigmentation from hydroxychloroquine to be as high as 33% of individuals. Elder abuse is a cause of significant morbidity and mortality in older individuals 7–9.