Parasites that cause malaria typically enter the body through the bite of a mosquito. Malaria is common in areas such as Africa, South America, and Southern Asia. The trade name of chloroquine is 3-hydroxychloroquine Do i need to take folic acid with plaquenil Chloroquine phosphate for ich Chloroquine works to treat malaria by killing the Plasmodium parasites that cause the infection. This eMedTV segment describes chloroquine's mode of action and provides a link to more detailed information on this medication. Mechanism of action of chloroquine. Entry into the parasitized RBCs; 1. Accumulation in food vacuole of the parasite- role of pH gradient chloroquine trapping Affects asexual cycle of plasmodium specie. Once administered, it has to enter site of action. It rapidly enters and gets concentrated in food vacuole, present within erythrocytes. Chloroquine is an antimalarial drug. It is also used for other medical conditions. It is not exactly known how its mechanism of action works but it is suspected to inhibit certain enzymes from its interaction with DNA. Chloroquine Clinical Indications. Chloroquine was originally made for the treatment of malaria. Chloroquine is also used to treat amebiasis (infection caused by amoebae). Chloroquine is used to treat and to prevent malaria. What is the mode of action of chloroquine Chloroquine mechanism of drug action and resistance in., Chloroquine – howMed Bowman nodules hydroxychloroquineWhat is the cheapest alternatives to plaquenilPlaquenil guidelines aoaUsing pei vs chloroquine transfectionMalaria drug combined mice chloroquine 17 Chloroquine- resistant parasites accumulate less chloroquine in the food vacuole than do sensitive parasites Fitch, 1970 and one assumption is that chloroquine resistance is not based on the mode of action of the drug but on the access of the drug to the parasite food vacuole. Antimalarial drugs Mode of action and status of resistance. Chloroquine or Hydroxychloroquine Plaquenil and the Ocular Effects. Chloroquine Uses, Side Effects & Warnings -. A severe eye problem has happened with chloroquine. This may lead to lasting eyesight problems. The risk may be higher if you have some types of eye or kidney problems. The risk may also be higher with some doses of chloroquine, if you use chloroquine for longer than 5 years, or if you take certain other drugs like tamoxifen. Chloroquine has a negative inotropic action, inhibits spontaneous diastolic depolarization, slows conduction, lengthens the effective refractory period and raises the electrical threshold. This results in depression of contractility, impairment of conductivity, decrease of excitability, but with possible abnormal stimulus re-entry mechanism. Chloroquine and hydroxychloroquine are drugs derived from the quinoline molecule. Both are used as antimalarial blood schizonticides, and hydroxychloroquine is also frequently used as an antirheumatic. Their mechanism of action is not entirely understood.