Pattern of Retinopathy: Although the locus of toxic damage is parafoveal in many eyes, Asian patients often show an extramacular pattern of damage. Dose: We recommend a maximum daily HCQ use of 5.0 mg/kg real weight, which correlates better with risk than ideal weight. Chloroquine hydrochloride properties Hydroxychloroquine copay assistance Treatment malaria chloroquine SD-OCT scan from a 44-year-old woman with bilateral plaquenil toxicity. There is damage visible in the outer retina in a perifoveal distribution. Researchers recently reported on early optical coherence tomography OCT abnormalities due to HCQ toxicity that may develop through normal visual field VF testing. They found that patients with high-risk HCQ exposure and normal VF testing may develop subtle but characteristic OCT abnormalities. SD-OCT is an objective test for toxicity that complements 10-2 visual field testing. 10-2 visual testing is probably more sensitive, but is heir to interpretational difficulties and variability not so much a problem with SD-OCT. Risk of Toxicity: The risk of toxicity is dependent on daily dose and duration of use. There are no similar demographic data for CQ, but dose comparisons in older literature suggest using 2.3 mg/kg real weight. Oct image plaquenil toxicity Despite Plaquenil dosing recommendations, retinal toxicity., Spotting the Telltale Signs of Plaquenil Toxicity Does plaquenil need to be tapered In analyzing SD-OCT, it is imperative to pay special attention to the outer retina Figure 3. Thinning of the photoreceptor layer, ellipsoid layer, outer nuclear layer, and RPE can be among the earliest signs of hydroxychloroquine toxicity. 4 These changes often occur in the parafoveal area, although they can be more peripheral in Asian patients. Retina Today - Imaging in Hydroxychloroquine Toxicity.. Hydroxychloroquine Retinopathy with SD-OCT Changes and.. Time Domain OCT in Hydroxychloroquine Plaquenil Toxicity - The Retina.. Uploaded on Dec 6, 2016. Last modified by Caroline Bozell on Dec 7, 2016.; Rating Appears in Miscellaneous Condition/keywords plaquenil toxicity Description 70-year-old woman with history of plaquenil use for rheumatoid arthritis. Dosage levels that can cause toxicity 6.5 mg/kg Hydroxychloroquine Plaquenil19 3 mg/kg Chloroquine Arlen With Plaquenil Plaquenil is manufactured in only a 200 mg tablet The typical dosage is either 200 or 400 mg per day 200 mg daily puts anyone under 68 pounds at risk1 Many systemic medications may cause retinal toxicity. One such commonly used medication for dermatologic and rheumatologic inflammatory conditions is hydroxychloroquine Plaquenil, a chloroquine derivative. It is used to treat many diseases including malaria, rheumatoid arthritis and systemic lupus erythematosus.