I've stopped Sulfa as I was experiencing a bad taste & smell, which may be caused by sulfa. After a while it wasn't as effective and I too was prescribed methotrexate alongside. I'm about to start MTX & am hoping that I wont have side effects with that! The side effects of the methotrexate for me were horrendous (chronic chest infections) and I'm now asthmatic as a result. Cheap aralen 500mg Hydroxychloroquine sulphate overdose Plaquenil for scarring alopecia Hydroxychloroquine and loratadine Sulfasalazine comes as regular and delayed-release enteric-coated tablets. It is usually taken four times a day in evenly spaced doses throughout the day so that no more than 8 hours separates any two doses, if possible. Take sulfasalazine exactly as directed by your doctor. Hi, I was diagnosed with RA and was put on sulfa, my rheumy tried adding mtx but i had awful side effects so am now on hydroxychloroquine and sulfa.this combination worked for anyone? just wondered how other people got on with it. Jan 01, 2006 Combination therapy was associated with significantly fewer withdrawals 8 vs. 29%; P = 0.0008 ; withdrawals as a result of lack of efficacy and adverse events were also lower in the group receiving combination therapy 8 vs. 25% compared with sulfasalazine alone. However, combination therapy was associated with more frequent adverse events, such as infection, gastrointestinal complaints, and cardiovascular disorders. I had side effects from MTX, which largely wore off, but haven't had any problems with the Hydroxy or Sulpha. I refuse to take it now even if its my passport to biologic treatment. I started with MTX which worked, but not enough so the others were added in which has been better. Sulfasalazine vs plaquenil Taking plaquenil and sulfasalazine Arthritis Information, Combination hydroxychloroquine and sulfasalazine - do. Plaquenil and methotrexate togetherHow do i know if i'm allergic to hydroxychloroquine Sulfasalazine also is available in an enteric-coated stomach-coated pill that helps prevent nausea and abdominal discomfort. Sun sensitivity of the skin can also be a a side effect. Those on sulfasalazine should use sunscreen SPF 15 or higher when outdoors and avoid prolonged exposure to sunlight. Sulfasalazine Azulfidine. Combination Therapy for Rheumatoid Arthritis in the Era of.. Compare Sulfasalazine vs Plaquenil -. An important and much‐studied group of patients with RA is the group who have had only a partial or a suboptimum response to MTX. A number of studies have enrolled this type of patient and have randomized patients to receive active therapy or placebo in addition to their baseline MTX therapy 9, 11, 13-15. I took it when first diagnosed and turned out to have a terrible allergy-not to the sulfa, but to the quinine in the drug. The itching was unreal and took 3 weeks to get our of my system. I do take sulfasalazine-another sulfa drug that doesn't act like one. My rhuemy told me not to take any others because some regular slafa drugs can cause flares. Sulfasalazine is used to treat a certain type of bowel disease called ulcerative colitis. This medication does not cure this condition, but it helps decrease symptoms such as fever, stomach pain, diarrhea, and rectal bleeding.