Why malaria becomes resistant to chloroquine

Discussion in 'Canada Pharmaceuticals Online' started by simros, 25-Feb-2020.

  1. berkutik XenForo Moderator

    Why malaria becomes resistant to chloroquine


    Artemisinin Combination Therapies, or ACTs, are currently the frontline treatments against malaria. Although these treatments are working well in many parts of the world, there is serious concern that malaria parasites are once again developing widespread resistance to this vital treatment.

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    Each ACT is a combination of two or more drugs that work against the malaria parasite in different ways. Chloroquine phosphate. Chloroquine is the preferred treatment for any parasite that is sensitive to the drug. But in many parts of the world, the parasites that cause malaria are resistant to chloroquine. Chloroquine, an old malaria drug, may help treat novel coronavirus, doctors say Chloroquine, or hydroxychloroquine, has been used to treat malaria since 1944. Drug-resistant P. falciparum. Chloroquine-resistant P. falciparum first developed independently in three to four areas in Southeast Asia, Oceania, and South America in the late 1950s and early 1960s. Since then, chloroquine resistance has spread to nearly all areas of the world where falciparum malaria is transmitted.

    The cause of the most lethal human malaria, chloroquine resistance is linked to multiple mutations in Pf CRT, a protein that likely functions as a transporter in the parasite’s digestive vacuole membrane. As the threat of antimalarial drug resistance grows, there is increasing pressure to sustain the efficacy of existing treatments, develop alternative treatments, as well putting in place preventative measures such as bednets.

    Why malaria becomes resistant to chloroquine

    Chloroquine MedlinePlus Drug Information, Chloroquine, an old malaria drug, may help treat novel coronavirus.

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  7. If a child takes chloroquine by accident, get medical help right away. If you are 65 or older, use chloroquine with care. You could have more side effects. Tell your doctor if you are pregnant or plan on getting pregnant. You will need to talk about the benefits and risks of using chloroquine while you are pregnant. Preventing malaria

    • Chloroquine Indications, Side Effects, Warnings -.
    • CDC - Malaria - Malaria Worldwide - How Can Malaria Cases and Deaths Be..
    • Medicines for the Prevention of Malaria While Traveling..

    Do not use Chloroquine phosphate tablets for the treatment of complicated malaria high-grade parasitemia and/or complications e.g. cerebral malaria or acute renal failure. Do not use Chloroquine phosphate tablets for malaria prophylaxis in areas where Chloroquine resistance occurs, Resistance to Chloroquine phosphate tablets is widespread in P. falciparum, and is reported in P.vivax see WARNINGS. Chloroquine was first discovered in the 1930s in Germany and began to be widely used as an anti-malaria post-World War II, in the late 1940s. However, resistance to the drug also rapidly emerged, with the first cases of Plasmodium falciparum not being cured by administration of chloroquine being reported in the 1950s. A In most parts of the world, falciparum malaria has become resistant to conventional treatment, such as chloroquine, sulfadoxine-pyrimethamine, and other antimalarial medicines used on their own. This is why WHO recommends that countries use a combination of drugs to fight malaria.

     
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    Keep using this medicine for the full treatment time, even if you feel better after the first few doses. Hydroxychloroquine MedlinePlus Drug Information Stopping Methotrexate - Arthritis Information Plaquenil Withdrawal – Life As An Anomaly
     
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