Please review the following URL and make sure that it is spelled correctly. Plaquenil is the brand name for the prescription drug hydroxychloroquine. Plaquenil patient assistance application Delayed pressure urticaria hydroxychloroquine Plaquenil toxicity vf Plaquenil sarcoidosis treatment Hydroxychloroquine Plaquenil is also a disease-modifying anti-rheumatic drug DMARD used to treat both acute and chronic rheumatoid arthritis, systemic lupus erythematosus, and discoid lupus erythematosus. Dosage for Plaquenil. The adult dose of Plaquenil to suppress malaria is 400 mg on the same day each week. The pediatric weekly suppressive dosage is 5 mg/kg of body weight. The adult dose of Plaquenil to treat an acute attack of malaria is an initial dose of 800 mg followed by 400 mg in six to eight hours and 400 mg for two more days. If experienced, these tend to have a Severe expression. Abnormal Liver Function Tests. Acute Liver Failure. Acute Pustular Eruptions On Skin. Bronchospasm. Decreased Blood Platelets. Decreased White Blood Cells. Deficiency Of Granulocytes A Type Of White Blood Cell. Malaria is spread by mosquitoes, which transmit the parasites that cause the infection, usually in tropical and subtropical parts of the world. It's used to treat and prevent malaria infection, and to reduce symptoms and progression of autoimmune diseases such as lupus, rheumatoid arthritis, and others. Plaquenil and psychosis PLAQUENIL®, Side Effects of Plaquenil Hydroxychloroquine, Warnings, Uses Lysosomal degradation inhibitor chloroquineChloroquine and proguanil malariaPlaquenil and nerve painLupus miliaris disseminatus faciei hydroxychloroquine Yes, Plaquenil can cause mood changes, irritability and psychosis and can worsen the existing psychosis. So yes, changing the drug may help. However, please do not change or stop the medication on your own. You need to consult a doctor and slowly be weaned off it and on to anew drug for your lupus. Take care! PLAQUENIL = MENTAL PROBLEMS. - Autoimmune Disorders - MedHelp. Common and Rare Side Effects for Plaquenil Oral. Psychosis Likely Induced by Hydroxychloroquine in a Patient.. Yes, Plaquenil can cause mood changes, irritability and psychosis and can worsen the existing psychosis. So yes, changing the drug may help. However, please do not change or stop the medication on your own. You need to consult a doctor and slowly be weaned off it and on to anew drug for your lupus. Psychotic states are mimicked by the use of many drugs including amphetamines, cannabis, lysergic acid diethylamide, psilocybin, mescaline, isoniazid, and L-dopa. A paranoid psychotic picture in a clear sensorium is characteristic of amphetamine psychosis. Please I need to find out if anyone who has taken plaquenil has experienced back and hip pain. I started in Oct of 2011 taking 200 mg of plaquenil once a day. In April of 2012 I started taking 400 mg 2 x's a day. I did start to notice that I was having pain when I tried to sleep at night. Mostly in my arms hands and ankles.