Pattern of Retinopathy: Although the locus of toxic damage is parafoveal in many eyes, Asian patients often show an extramacular pattern of damage. Dose: We recommend a maximum daily HCQ use of 5.0 mg/kg real weight, which correlates better with risk than ideal weight. Does plaquenil make you immunosuppressed Is plaquenil used for osteoarthritis Chloroquine hallucinations robert bale H ydroxychloroquine HCQ; Plaquenil, Sanofi, Bridgewater, NJ is an antimalarial agent that is also commonly used as a treatment for a variety of rheumatologic and dermatologic conditions, such as rheumatoid arthritis and systemic lupus erythematosus. The most common side effect associated with its use is retinal toxicity, which may be irreversible. Nov 01, 2015 H ydroxychloroquine HCQ; Plaquenil, Sanofi, Bridgewater, NJ is an antimalarial agent that is also commonly used as a treatment for a variety of rheumatologic and dermatologic conditions, such as rheumatoid arthritis and systemic lupus erythematosus. The most common side effect associated with its use is retinal toxicity, which may be irreversible. Hydroxychloroquine can cause irreversible retinal toxicity, resulting in bilateral bull’s eye retinopathy, but is regarded as less toxic to the retina than chloroquine and it does not cause the corneal deposits seen with chloroquine therapy. Irreversible retinal toxicity from hydroxychloroquine has been recognised for many years, with the. Risk of Toxicity: The risk of toxicity is dependent on daily dose and duration of use. There are no similar demographic data for CQ, but dose comparisons in older literature suggest using 2.3 mg/kg real weight. Retinal toxicity associated with hydroxychloroquine and chloroquine Chloroquine - Wikipedia, Retinal Physician - Hydroxychloroquine Maculopathy An Update. Plaquenil dermatomyositis One of the most important appears to be dosage, with daily intake believed to be more significant than cumulative dosage. 6,18,19 Indeed, the majority of cases of retinal toxicity have been associated with a daily dosage of hydroxychloroquine of 6.5 mg/kg or more based on actual body weight. 6,18,19 Of the 12 patients in our series who were receiving hydroxychloroquine for whom daily dosage could be calculated, we identified 8 patients who had developed retinal toxicity despite daily. Retinal Toxicity Associated With Hydroxychloroquine and Chloroquine.. Hydroxychloroquine DermNet NZ. Hydroxychloroquine-Induced Retinal Toxicity - American.. CLINICAL SCIENCES Retinal Toxicity Associated With Hydroxychloroquine and Chloroquine Risk Factors, Screening, and Progression Despite Cessation of Therapy Co-existing liver and kidney disease may also impact on the genesis of plaquenil retinal toxicity. One additional issue is the fact that chloroquine and hydroxychloroquine are cleared by both the liver and kidney. Any compromise of these organs may also impact on potential toxicity. Said another way. Hydroxychloroquine has significantly less retinal toxicity and has largely replaced chloroquine as a treatment of inflammatory disease. Unfortunately, the retinal damage from these medications is largely irreversible, so it is critical to detect early retinal toxicity in the hopes of limiting the extent of visual loss.