It can decrease the pain and swelling of arthritis. It may prevent joint damage and reduce the risk of long-term disability. Effects of plaquenil in pregnancy Cost hydroxychloroquine Hydroxychloroquine eye floater The Plaquenil is supposed to kick in in 3 to 6 months. I think it was 8 months for me. One day I was congratulating myself for getting so many things done and I realised that the days had been getting better without my noticing. In the beginning I also was on a low dose of prednisone, which helped until plaquenil kicked in. Because Plaquenil is the kind of drug that builds up in the blood stream and tissues I suspect, it has a very long half life. Simple drugs like abx can take as much as a month to completely clear from the body. Hi. I have been taking Plaquenil since July 9, 2006 6 weeks and I do not notice results so far. For those of you who have taken it, how long does it take to work and how will I know it's starting to work? I really appreciate your response. I have arthritis in my feet and ankles. Today, it is used to treat rheumatoid arthritis, some symptoms of lupus, childhood arthritis (or juvenile idiopathic arthritis) and other autoimmune diseases. Hydroxychloroquine is in a class of medications that was first used to prevent and treat malaria. How long does it take plaquenil to affect bones Side Effects of Plaquenil Hydroxychloroquine, Warnings, Uses, Plaquenil - how long for side effects to subside? How effective is plaquenil for rheumatoid arthritisDetoxing from plaquenilHydroxychloroquine mechanism of action arthritis Find information about common, infrequent and rare side effects of Plaquenil Oral. Common and Rare Side Effects for Plaquenil Oral. Bone Joint Muscle - Arthritis Plaquenil - How long till it works.. Hydroxychloroquine - Wikipedia. Hi. I have been taking Plaquenil since July 9, 2006 6 weeks and I do not notice results so far. For those of you who have taken it, how long does it take to work and how will I know it's starting to work? I really appreciate your response. I have arthritis in my feet and ankles. I still take Tylenol but my Been on plaquenil close to 3 months now and haven't noticed any side effect so far. Eye problems is one of the more serious side effects from plaquenil that you hear people talk about. My rheumy says it's mostly long term that causes the eye problems but recommends me to keep regular eye exams. For those of you who take calcium tablets, I saw on there is a facility to check drug interactionsthat taking Plaquenil at the same time with calcium could reduce the efficacy of Plaquenil by up to 50%. To get around that, it is best to leave 4 hours between taking either of them.