They are most common among people with weak immune systems. People with certain health conditions may need to take medications with side effects that can weaken your immune system and put you at risk for fungal infections. Cellulitis of leg and plaquenil Plaquenil and liver failure Cheap aralen malaria Chloroquine aims for blood stages Aug 25, 2011 I'm not a healthcare provider, but I do take Plaquenil and just found out from another user of it that it does suppress the immune system. I didn't know that when I started taking it for Sjogren's in November 2011. In January 2012, I had a horrible cold, stomach flu and then SHINGLES. Hydroxychloroquine Plaquenil is considered a disease-modifying anti-rheumatic drug DMARD. It can decrease the pain and swelling of arthritis, prevent joint damage and reduce the risk of long- term disability. Hydroxychloroquine is in a class of medications that was first used to prevent and treat malaria. Hydroxychloroquine Plaquenil is considered a disease-modifying anti-rheumatic drug DMARD. It can decrease the pain and swelling of arthritis. It may prevent joint damage and reduce the risk of long-term disability. Hydroxychloroquine is in a class of medications that was first used to prevent and treat malaria. Fungal infections can range from mild to life-threatening. Specifically, corticosteroids and TNF (tumor necrosis factor) inhibitors are two types of medications that can increase your chances of getting a fungal infection. How does plaquenil work on the immune system What Is Plaquenil? - American Academy of Ophthalmology, PATIENT FACT SHEET Hydroxychloroquine Plaquenil Plaquenil and liver damage Nov 15, 2016 I have been taking Plaquenil hydroxychloroquine for about 10 months. Since August I’ve had some strange infections. First I got shingles. Then I started with a bacterial vaginosis. I discontinued the Plaquenil for about a week when I was diagnosed with shingles and I thought it may have helped it not be so bad. The bacterial vaginosis just won’t go away. I use metro gel and it’s goes. Does Plaquenil hydroxychloroquine impact my immune system.. Hydroxychloroquine Plaquenil. Plaquenil and its affect on the immune system DailyStrength. Plaquenil tablets contain the active ingredient hydroxychloroquine, which is a type of medicine called a disease-modifying anti-rheumatic drug DMARD. It is used to treat rheumatoid arthritis. I doubt it is the Plaquenil affecting your immune system, but the actual Lupus itself as it can affects the white blood cells and lower them so we get every infection going. You need to speak to your rheumy for more clarification in your case. Plaquenil itself probably does not have a direct affect on your immune system - it is a DMARD and is not considered to be an immunosuppressant. However, many with active autoimmune diseases feel that they are not succeptible to many of the common viruses that they are exposed to - somewhat of a silver lining.