Chloroquine in vitro concentrations

Discussion in 'Canadian Pharmacies Online' started by Nova_an, 12-Mar-2020.

  1. freemninvic New Member

    Chloroquine in vitro concentrations

    Chloroquine has been extensively used in mass drug administrations, which may have contributed to the emergence and spread of resistance. It is recommended to check if chloroquine is still effective in the region prior to using it.

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    Researchers at the Belgian Catholic University of Leuven found that chloroquine inhibited SARS coronavirus replication with a 50% effective concentration of 88 SE 12 μmol/L, within the range of blood concentrations achievable during antimalarial treatment. Mar 09, 2020 Using the PBPK models, hydroxychloroquine concentrations in lung fluid were simulated under 5 different dosing regimens to explore the most effective regimen whilst considering the drug's safety profile. RESULTS Hydroxychloroquine EC50=0.72 μM was found to be more potent than chloroquine EC50=5.47 μM in vitro. The antimalarial drug chloroquine has been suggested as a treatment for Ebola virus infection. Chloroquine inhibited virus replication in vitro, but only at cytotoxic concentrations. In mouse and hamster models, treatment did not improve survival. Chloroquine is not a promising treatment for Ebola. Efforts should be directed toward other drug classes.

    The Centers for Disease Control and Prevention recommend against treatment of malaria with chloroquine alone due to more effective combinations. In areas where resistance is present, other antimalarials, such as mefloquine or atovaquone, may be used instead.

    Chloroquine in vitro concentrations

    Plasma chloroquine and desethylchloroquine concentrations in., In Vitro Antiviral Activity and Projection of Optimized.

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  3. Chloroquine CQ triggers G0/G1 cell cycle arrest. A HepG2 and B Huh7 cells were treated with CQ at different concentrations for 24 h, followed by PI staining and fluorescence-activated cell sorting FACS analysis for the cell cycle profile. Representative.

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    May 29, 2006 It has biochemical properties that could be applied to inhibit viral replication. We report here that chloroquine is able to inhibit influenza A virus replication, in vitro, and the IC50s of chloroquine against influenza A viruses H1N1 and H3N2 are lower than the plasma concentrations reached during treatment of acute malaria. If chloroquine should indeed inhibit the biosynthesis of sialic acid, this effect could explain not only the effects of chloroquine on HIV and SARS coronavirus sialic acid moieties are present in HIV-1 glycoproteins and SARS coronavirus receptor ACE2, but also the in-vitro effects on orthomyxoviruses which use sialic acid moieties as receptors Chloroquine was detectable in plasma within 30 min of giving the drug. Peak level was reached in 1-8 h after the first dose of 10 mg/kg and the peak concentrations ranged between 65 and 263 ng/ml. Chloroquine concentration declined slowly in plasma after stopping drug administration so that the concentration at the seventh day was 37.5% of the concentration on the third day.

  4. if_host User

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  5. Astana XenForo Moderator

    Plaquenil - FDA prescribing information, side effects and uses Plaquenil is not recommended for malaria prophylaxis in geographic areas where chloroquine resistance occurs. • Plaquenil does not prevent relapses of P. vivax or P. ovale because it is not active against the hypnozoite forms of these parasites.

    Hydroxychloroquine Oral Route Description and Brand Names.
  6. 00110011 New Member

    Treating Lupus with Anti-Malarial Drugs Johns Hopkins Lupus. With Plaquenil, however, the most commonly prescribed anti-malarial, this sort of damage occurs only in 1 out of 5,000 people who take the drug for five years or more. For this reason though, it is important that you see an ophthalmologist for an exam before starting to take an anti-malarial medication for your lupus.

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