The doctor said that given where I am right now (constant low level pain and light swelling of my hands and wrists but no joint damage showing up on xrays or the ultrasound), she gave me a choice of starting on either Plaquenil or Methotrexate. She went over some info on each drug and then gave me some time to think about which would be better for me. My largest concerns center around the side effects of each... Chloroquine overdose side effects Lupus alternatives to plaquenil Was the plaquenil controlling your RA symptoms? The trouble is you lose hair on Methotrexate too. But after losing heaps when I first went on it, I have stabalised now, I have thinner hair but it still looks fine and healthy. If plaq was working for your symptoms I'd go back on it. If you feel like the RA is escallating then go for mtx. Dec 15, 2010 hello hope everyone is well just a quick question, i have been on methotrexate for 2 months increasing from 7.5 to 15 and now to 25mg.weekly now been given plaquenil 400mg daily, has anyone else been on this mixture and has it worked or how long should i wait to see if it works. Between groups per-protocol analysis after intervention Mean SD LPPAI in methotrexate group at baseline, 4.63 1.83, was significantly higher than that in hydroxychloroquine group, 3.46 0.94, P = 0.04. reveals LPPAI difference between the two groups at I also want to be sure that I'm taking a drug that will slow/stop the progression of the disease. With Plaquenil, the possibility of permanent vision damage scares me. Difference between hydroxychloroquine and methotrexate Combination therapy with methotrexate and hydroxychloroquine., Methotrexate and plaquenil - How long is plaquenil goodPlaquenil safer than floroquinolonesHow can you get hydroxychloroquinePlaquenil for inflammatory arthritis Hydroxychloroquine Plaquenil is used to treat malaria, lupus, and rheumatoid arthritis. Learn about side effects, warnings, dosage, and more. Hydroxychloroquine Side Effects, Dosage, Uses, and More. Clinical efficacy and safety of methotrexate versus.. Common Questions About Taking Methotrexate for Rheumatoid.. In a word, yes. Not actual vomiting, but distinct nausea and muzzyness. Worst of all depression. As the addition of Hydroxychloroquine to my cocktail methotrexate and Enbrel Anti-TNF, didn't seem to be making any difference, I stopped it a few weeks ago. I was diagnosed with RA in march and have been on increasing dose of methotrexate. Yesterday my rheumatologist started me on hydroxychloroquine as well. Is anyone else on this combination and have you had any problems with it as I know hydroxychloroquine can cause eye sight problems. Thanks Plaquenil hydroxychloroquine is an effective medication for autoimmune conditions and malaria that comes with less side effects than other DMARDs. Effectively prevents and treats malaria, and treats a certain type of intestinal infection but can cause serious side effects in certain people.