Treatment is usually initiated by a specialist, but GPs play an important role in monitoring patients for adverse effects and drug interactions. This article includes a pull out DMARD monitoring table and information on tumour necrosis factor (TNF) inhibitors. Hydroxychloroquine tablets ip hcqs-400 Chloroquine phosphate inverts Give the synthesis of chloroquine In combination with methotrexate for active disease in adult patients when the response to disease-modifying anti-rheumatic drugs DMARDs including methotrexate has been inadequate, or the treatment of severe, active and progressive disease in adults not previously treated with methotrexate or other DMARDs. Ankylosing spondylitis. Apremilast, hydroxychloroquine, mepa-crine or minocycline. Standard monitor-ing is recommended for azathioprine, sodium aurothiomalate, leflunomide and mycophenolate mofetil, and for 12 months for sulfasalazine. Monthly monitoring should be extended long-term for ciclosporin, methotrexate plus leflunomide and tacrolimus but less frequent monitor- Hydroxychloroquine Plaquenil is considered a disease-modifying anti-rheumatic drug DMARD. It can decrease the pain and swelling of arthritis. It may prevent joint damage and reduce the risk of long-term disability. Hydroxychloroquine is in a class of medications that was first used to prevent and treat malaria. Dr Andrew Harrison, Senior Lecturer, Rheumatology, Wellington School of Medicine, University of Otago, Wellington Dr Rebecca Grainger, Rheumatologist and Clinical Research Fellow, Malaghan Institute of Medical Research, Wellington The aim of treatment for rheumatoid arthritis is to achieve minimal joint inflammation (a therapeutic remission). Key reviewers: Professor John Highton, Head of Section, Department of Medical and Surgical Sciences, Dunedin School of Medicine, University of Otago. Hydroxychloroquine methotrexate sulfasalazine azathioprine lefludomide As methotrexate azathioprine sulfasalazine., Prescribing and monitoring non-biological DMARDs Hydroxychloroquine crushPlaquenil brand vs genericPlaquenil sanofi aventis It can either be prescribed alone or in combination with other treatments, such as methotrexate; often leflunomide is prescribed for patients who do not respond well to methotrexate. Leflunomide works by blocking the formation of DNA in the cells of your body, including those of the immune system. Treating Lupus with Immunosuppressive Medications Johns.. Hydroxychloroquine Plaquenil. Is Leflunomide as Safe and Effective in the Treatment of.. Original Article from The New England Journal of Medicine — Treatment of Rheumatoid Arthritis with Methotrexate Alone, Sulfasalazine and Hydroxychloroquine, or a Combination of All Three Medications Methotrexate is one of the most durable and frequently used disease-modifying antirheumatic drugs DMARDs in monotherapy as well as the cornerstone of combination therapy for rheumatoid arthritis RA. Leflunomide, sulfasalazine, and hydroxychloroquine are effective therapies in RA and are commonly employed in combination therapy. Sulfasalazine is a combination of sulfapyridine and aspirin like compounds. The medication may be associated with diminution in complete blood cell count. In general, one should consider withdrawal of the medication three or four days prior to surgery. Hydroxychloroquine is a less commonly utilized disease modifying anti-rheumatic medication.