Both medications are commonly used to treat patients with systemic autoimmune diseases that include the following: The pathogenic effect of plaquenil is the induction of lysosomal dysfunction in photoreceptors and retinal pigment epithelium (RPE) cells. A lysosome is a membrane-bound organelle found in the cytoplasm of most cells and it contains hydrolytic enzymes that function in intracellular digestive processes. What happens when you stop plaquenil Plaquenil lyme arthritis Hydroxychloroquine bleaching cream How quickly does plaquenil work Hydroxychloroquine Maculopathy An Update on Screening and Diagnosis A brief guide for imaging SHIRI SHULMAN, MD. H ydroxychloroquine HCQ; Plaquenil, Sanofi, Bridgewater, NJ is an antimalarial agent that is also commonly used as a treatment for a variety of rheumatologic and dermatologic conditions, such as rheumatoid arthritis and systemic lupus erythematosus. Start studying Plaquenil Problems. Learn vocabulary, terms, and more with flashcards, games, and other study tools. The appearance of disruption of the photoreceptor integrity line, perifoveal thinning, and paracentral scotomas confirmed a high likelihood of toxicity in this patient. She was asked to stop the medication immediately, which she did. In the normal retina, the retinal pigment epithelium digests the tips of the photorectors by lysosomal action. When hydrolytic enzymes are released into the cytoplasm, they cause self-digestion of the cell. Photoreceptor integrity line plaquenil Early Plaquenil Toxicity Detected without Bull’s Eye Maculopathy, Plaquenil Problems Flashcards Quizlet Chloroquine rx So You Think Checking For Plaquenil Toxicity Will Not Make A Difference? A STORY THAT NEEDS TO BE TOLD. Recently new guidelines for the management of patients taking PLAQUENIL were released. So You Think Checking For Plaquenil Toxicity Will Not Make A Difference?. Determine risk for hydroxychloroquine retinal toxicity.. Lecture Interpretation of OCT Retina from A-Z Cybersight. SD-OCT will reveal parafoveal thinning of the photoreceptor integrity line and the outer nuclear layer of the retina; this results in a "flattening" of the foveal depression and the "flying saucer sign" where the outer nuclear layer in the fovea's center is unaffected, and just around it this layer is much thinner the edge of the saucer. The prominent bright band anterior to or above the RPE is labeled the photoreceptor integrity line PIL and has had several names over the past decade Initially it was termed the connecting cilia, then later the junction of the inner and outer segments of the photoreceptors, followed by the PIL and, most recently, as the inner segment. The ellipsoid zone EZ, which has had a contentious naming history and has previously been called the connecting cilia, inner segment-outer segment junction, photoreceptor integrity line, and inner ellipsoid zone, is significantly reflective and separates the myoid zone and the photoreceptor outer segments.3. The integrity of the EZ often.