Our team periodically reviews articles in order to ensure content quality. The sources cited below consist of evidence from peer-reviewed journals, prominent medical organizations, academic associations, and government data. Plaquenil macular hole Malarone versus chloroquine What does plaquenil do to your immune system Kidney and liver disease predispose to hydroxychloroquine toxicity due to impaired clearance of the drug. Old age is hypothesized to contribute to overall risk due to the natural aging process of the retinal pigment epithelium RPE, causing the RPE to be more sensitive to toxic drugs. Side effects. In some people, HCQ may cause gastrointestinal problems, such as nausea, vomiting, upset stomach, cramps, or diarrhea. These may occur for the first few days a person takes the drug while the body adjusts to the medication. Loss of appetite, tiredness, weakness, or headache are uncommon side effects and typically go away over time. Aug 14, 2017 Long-Term Side Effects of Plaquenil for Rheumatoid Arthritis. Plaquenil is the brand name of hydroxychloroquine, a drug used to prevent or treat malaria. Plaquenil is also used for long-term treatment of autoimmune diseases such as rheumatoid arthritis RA and systemic lupus erythmatosis. Please check with the appropriate physician regarding health questions and concerns. The information contained on this site is for informational purposes only, and should not be used as a substitute for the advice of a professional health care provider. Hydroxychloroquine effects on kidneys Hydroxychloroquine Reduces Chronic Kidney Disease CKD Risk., Drug spotlight on hydroxychloroquine Lupus Foundation of America Hydroxychloroquine hair growthHydroxychloroquine msHydroxychloroquine 200 mg used forHow quickly does damage from plaquenil In rare cases, hydroxychloroquine can cause visual changes or loss of vision. Such vision problems are more likely to occur in individuals taking high doses for many years, individuals 60 years or older, or those with significant kidney disease. At the recommended dose, development of visual problems due to the medication is rare. Hydroxychloroquine Plaquenil. Long-Term Side Effects of Plaquenil for Rheumatoid Arthritis.. Hydroxychloroquine Side Effects Common, Severe, Long Term.. Side-effects aren't common. However, in some people hydroxychloroquine can cause skin rashes, especially those made worse by sunlight. feeling sick nausea or indigestion. diarrhoea. headaches. bleaching of the hair or mild hair loss. tinnitus ringing in the ears Nov 09, 2018 Hydroxychloroquine Side Effects Get emergency medical help if you have signs of an allergic reaction hives; difficulty breathing; swelling of your face, lips, tongue, or throat. The effect of hydroxychloroquine on long-term kidney outcomes in rheumatoid arthritis remains unclear. In this study, we hypothesized that hydroxychloroquine use may be beneficial for reducing kidney diseases, and we conducted a nationwide observational cohort study to assess the associations between hydroxychloroquine use and long-term kidney outcomes in patients with rheumatoid arthritis.