Chloroquine and p62

Discussion in 'Chloroquin' started by white despair, 26-Feb-2020.

  1. flere New Member

    Chloroquine and p62


    Chloroquine has been extensively used in mass drug administrations, which may have contributed to the emergence and spread of resistance. It is recommended to check if chloroquine is still effective in the region prior to using it.

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    Moreover, elevated p62 is significantly correlated with poor survival in patients with breast cancer Supplementary Fig. S1, suggesting a role for autophagy in breast cancer recurrence. CQ is a lysotropic chloroquine derivative that accumulates within lysosomes, resulting in lysosome neutralization and the inhibition of autophagic flux. Through the detection of autophagy substrates p62 and LC3, found that QBC939 cells have a higher flow of autophagy, autophagy inhibitor chloroquine can significantly increase the sensitivity of cisplatin in cholangiocarcinoma cells compared with hepatocellular carcinoma HepG2 cells. Chloroquine is a lysosomotropic weak base, which in the monoprotonated form diffuses into the lysosome, where it becomes diprotonated and becomes trapped. Protonated chloroquine then changes the lysosomal pH, thereby inhibiting autophagic degradation in the lysosomes.

    The Centers for Disease Control and Prevention recommend against treatment of malaria with chloroquine alone due to more effective combinations. In areas where resistance is present, other antimalarials, such as mefloquine or atovaquone, may be used instead.

    Chloroquine and p62

    Akt and Autophagy Cooperate to Promote Survival of Drug., Autophagy inhibitor chloroquine increases sensitivity to cisplatin in.

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  6. P62 is not only involved in autophagy as an adaptor and in many cases, p62 is upregulated such as under proteasome inhibitor treatment under high doses and under the scenario of disturbance of Nrf2.

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    The expression of the autophagy markers LC3B and p62 were assessed via immunofluorescence and immunoblotting after pharmacological autophagy inhibition with chloroquine, which prevents the fusion of autophagosomes and lysosomes by increasing lysosomal pH, in HT-29 and LoVo CC cell lines. Dec 13, 2016 The interactions of p62 and the UPS, autophagy and ubiquitinated proteins. Upon UPS inhibition, p62 is upregulated and phosphorylated on S405 and S409, which can facilitate the degradation of ubiquitinated cargoes via autophagy. p62 synthesis is induced by an increase in Nrf2 following UPS deficiency. Conversely, chloroquine-treated VCPR155H/+ mice revealed progressive muscle weakness, cytoplasmic accumulation of TDP-43, ubiquitin-positive inclusion bodies and increased LC3-I/II, p62/SQSTM1, and optineurin expression levels. Our in vitro patient myoblasts studies treated with rapamycin demonstrated an overall improvement in the autophagy.

     
  7. Hydroxychloroquine is a quinoline medicine used to treat or prevent malaria, a disease caused by parasites that enter the body through the bite of a mosquito. Plaquenil - FDA prescribing information, side effects and uses Plaquenil hydroxychloroquine sulfate dose, indications, adverse. Plaquenil Uses, Dosage & Side Effects -
     
  8. pignus Well-Known Member

    A recent article published by the American Academy of Ophthalmology (AAO) presented new recommendations for screening of patients being managed with hydroxychloroquine (HCQ). EyeWiki - American Academy of Ophthalmology Hydroxychloroquine And Chloroquine Screening 2016 AAO Recommendations. This is Why You Need Multifocal ERG if You Have Plaquenil.
     
  9. petroff100 Well-Known Member

    Protective Effect of Hydroxychloroquine on Renal Damage in. Jun 15, 2009 In this study we have shown that hydroxychloroquine retards the development of renal damage in lupus nephritis patients after adjusting for confounding variables associated with its intake whether proteinuria is omitted from the end-point or not.

    Lupus Nephritis Treatment & Management Approach Considerations.