Malaria is common in areas such as Africa, South America, and Southern Asia. This medicine is not effective against all strains of malaria. Plaquenil and iron Hydroxychloroquine cystic fibrosis Patients who are genetically deficient in a certain enzyme, called G6PD, can develop a severe anemia resulting from the rupture of red blood cells. This enzyme deficiency is more common in persons of African descent and can be evaluated by blood testing. Hydroxychloroquine may worsen psoriasis. Hydroxychloroquine Plaquenil is a drug that is classified as an anti-malarial drug. Plaquenil is prescribed for the treatment or prevention of malaria. It is also prescribed for the treatment of rheumatoid arthritis, lupus, and the side effects of lupus such as hair loss, joint pain, and more. Safety and efficacy of hydroxychloroquine to treat lupus and arthritis have not been established in children. Glucose-6-phosphate dehydrogenase G6PD deficiency—May cause hemolytic anemia in patients with this condition. Kidney disease or Liver disease—Use with caution. The effects may be increased because of the slower removal of the. Taking hydroxychloroquine long-term or at high doses may cause irreversible damage to the retina of your eye. Hydroxychloroquine is also an antirheumatic medicine and is used to treat symptoms of rheumatoid arthritis and discoid or systemic lupus erythematosus. Hydroxychloroquine g6pd Glucose-6-phosphate dehydrogenase deficiency - Genetics Home., Hydroxychloroquine Plaquenil Side Effects & Dosage for Malaria Hydroxychloroquine not to mix with medicationChloroquine for treating malariaAdverse effects of plaquenilChloroquine resistant malaria Glucose-6-phosphate dehydrogenase G6PD is an enzyme in the pentose phosphate pathway see image, also known as the HMP shunt pathway. G6PD converts glucose-6-phosphate into 6-phosphoglucono-δ-lactone and is the rate-limiting enzyme of this metabolic pathway that supplies reducing energy to cells by maintaining the level of the reduced form of the co-enzyme nicotinamide adenine dinucleotide. Glucose-6-phosphate dehydrogenase deficiency - Wikipedia. Hydroxychloroquine Oral Route Before Using - Mayo Clinic. Hydroxychloroquine - Wikipedia. To cite this abstract in AMA style Mejia Saldarriaga M, Ramirez de Oleo IE, Johnson B. Retrospective Study Association of Hydroxychloroquine Use and Hemolytic Anemia in Patients with Low Levels of Glucose-6-Phosphate Dehydrogenase G6PD abstract. A genetic enzyme disorder such as porphyria or glucose-6-phosphate dehydrogenase G6PD deficiency. It is not known whether hydroxychloroquine will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant. Malaria is more likely to cause death in a pregnant woman. The first Web site established to offer information for G6PD deficient persons. Established in 1995 with the help of the late Ernest Beutler M. D. and the active support of Lucio Luzzatto M. D. Includes official list of drugs to avoid along with trade-names, printable brochure, forum and mailing lists.