Treatment of porphyria cutanea tarda with chloroquine

Discussion in 'Chloroquin' started by jeans, 13-Mar-2020.

  1. ddd- New Member

    Treatment of porphyria cutanea tarda with chloroquine


    Porphyria Cutanea Tarda (PCT) is a rare disorder characterized by painful, blistering skin lesions that develop on sun-exposed skin (photosensitivity). Affected skin is fragile and may peel or blister after minor trauma. PCT is essentially an acquired disease, but some individuals have a genetic (autosomal dominant) deficiency of UROD that contributes to development of PCT.

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    Chloroquine treatment can induce porphyria attacks within the first couple of months of treatment due to the mass mobilization of porphyrins from the liver into the blood stream. Complete remission can be seen within 6–12 months as each dose of antimalarial can only remove a finite amount of porphyrins and there are generally decades of accumulation to be cleared. Feb 27, 2019 Please use one of the following formats to cite this article in your essay, paper or report APA. Khetrapal, Afsaneh. 2019, February 27. Treatment of Porphyria cutanea tarda. Porphyria Cutanea Tarda PCT is the most common of the Porphyrias and results from a deficiency of the enzyme uroporphyrinogen decarboxylase UROD. Porphyria Cutanea Tarda PCT is a rare disorder characterized by painful, blistering skin lesions that develop on sun-exposed skin photosensitivity.

    Most individuals with the inherited enzyme deficiency remain latent and never have symptoms. These individuals are referred to as having "familial PCT".

    Treatment of porphyria cutanea tarda with chloroquine

    Porphyria Cutanea Tarda Treatment & Management Medical Care., Treatment of Porphyria cutanea tarda - News Medical

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  7. Porphyria cutanea tarda PCT is common in Ethiopia and invariably affects the liver. Treatment by abstension from alcohol and avoidance of direct sunlight often failed to achieve lasting improvement.

    • Chloroquine in the treatment of porphyria cutanea tarda..
    • Porphyria Cutanea Tarda PCT - American Porphyria Foundation.
    • How are acute porphyria and porphyria cutanea tarda treated?.

    Treatment of porphyria cutanea tarda PCT with chloroquine risks serious side‐effects so we have combined it with phlebotomy. One to four venesections were performed before the administration of chloroquine in to PCT patients. Equally high excretion of urinary porphyrins was achieved but the side‐effects were reduced. Introduction. Porphyria cutanea tarda PCT is the most common human porphyria, and is due to an acquired deficiency of hepatic uroporphyrinogen decarboxylase UROD activity, resulting in accumulation of the uroporphyrinogen and other highly carboxylated porphyrinogens in the liver, which then enter the plasma mostly as oxidized porphyrins and are excreted in urine. Because there is a strong association between Hepatitis C virus infection and porphyria cutanea tarda it is vital that the Hepatitis C virus infection is also treated if it shows that you have this medical condition. Porphyria cutanea tarda is normally treated first and then Hepatitis C virus infection is treated.

     
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