It may have both an anti-spirochaete activity and an anti-inflammatory activity, similar to the treatment of rheumatoid arthritis. And caution is required if patients have certain heart conditions, diabetes, psoriasis etc. Plaquenil slecht zien Hydroxychloroquine for systemic lupus erythematosus Chloroquine enters the red blood cell by simple diffusion, inhibiting the parasite cell and digestive vacuole. Chloroquine then becomes protonated to CQ2+, as the digestive vacuole is known to be acidic pH 4.7; chloroquine then cannot leave by diffusion. In the treatment of other systemic conditions, chloroquine raises the pH of vacuoles once the drug crosses the vacuolar membrane. Autoantigens, which are the main culprit in autoimmune disease, work best at an acidic pH. Therefore, chloroquine helps to decrease the effect of autoantigens. Chloroquine phosphate tablets should not be used in these conditions unless the benefit to the patient outweighs the potential risks. Usage in Pregnancy Usage of Chloroquine during pregnancy should be avoided except in the prophylaxis or treatment of malaria when the benefit outweighs the potential risk to the fetus. The most serious adverse effects affect the eye, with dose-related retinopathy as a concern even after hydroxychloroquine use is discontinued. The most common adverse effects are a mild nausea and occasional stomach cramps with mild diarrhea. Chloroquine ph Chloroquine diphosphate salt - Sigma-Aldrich, Chloroquine - American Osteopathic College of Dermatology. Alopecia plaquenilDoes plaquenil cause liver damageWhich autoimmune not treat with plaquenil Our Aralen chloroquine phosphate Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. Side Effects of Aralen Chloroquine, Warnings, Uses. Chloroquine - FDA prescribing information, side effects and uses. Chloroquine phosphate C18H32ClN3O8P2 - PubChem. Find patient medical information for Chloroquine Oral on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings. In addition, we have recently shown that chloroquine prevents and reverses pulmonary hypertension in a rat model of pulmonary hypertension characterized by loss of BMPR-II expression in the lung 13,21. Chloroquine is a lysosomotropic agent as it is usually prepared as a diprotic weak base pKa 8.5. Chloroquine is an anti-malaria medicine that works by interfering with the growth of parasites in the red blood cells of the human body. Parasites that cause malaria typically enter the body through the bite of a mosquito.