It's used to treat and prevent malaria infection, and to reduce symptoms and progression of autoimmune diseases such as lupus, rheumatoid arthritis, and others. Malaria is spread by mosquitoes, which transmit the parasites that cause the infection, usually in tropical and subtropical parts of the world. Plaquenil and lupus nephritis Plaquenil hair PLAQUENIL is indicated for the suppressive treatment and treatment of acute attacks of malaria due to Plasmodium vivax, P. malariae, P. ovale, and susceptible strains of P. falciparum. It is also indicated for the treatment of discoid and systemic lupus erythematosus, and rheumatoid arthritis. CONTRAlNDICATIONS I also have osteoarthritis. I started on Plaquenil in 2015 200 mg then increased to 400 mg after 3 months. It took many months for the ulcer like spots to go away but the drug works. In January 2018, I no longer had insurance so I dropped back down to 200 mg. It also took away most of my OA pain in my knees and hands. Painful Hand OA Not Relieved by Hydroxychloroquine. Exercise, not an immunosuppressant drug, may be most effective for hand OA pain. For example, it may be combined with an antibiotic to treat chronic Q-fever, which humans usually catch from farm animals or raw milk. Plaquenil is used to treat other types of infections too. Plaquenil for oa Hydroxychloroquine Reviews Everyday Health, Plaquenil Drug and Medication User Reviews on RxList Plasmodicidal action of chloroquineMethylene blue falciparum chloroquine reversalChloroquine malaria resistancePlaquenil price ukPlaquenil withdrawal side effects Nov 28, 2010 Plaquenil reduces inflammation in many Rheumatic disorders, the mode of action is pretty complicated though so I shan't bore you with all the details, but basically it prevents your dendritic cells these are messengers for your immune system, if you will from interacting with your T-Cells a special type of white blood cell which through a convoluted and boring process, causes inflammation when an infection is found, and these basically malfunction with inflammatory disorders. Inflammatory Osteoarthritis And Plaquenil. Painful Hand OA Not Relieved by Hydroxychloroquine Everyday.. Long-Term Side Effects of Plaquenil for Rheumatoid Arthritis. I am a 17 year old female with Juvenile Idiopathic Rheumatoid Arthritis. I take enbrel, methotrexate, and prednisone. I just spoke with my doctor at Vanderbilt Children’s Hospital, and he told me to continue taking all of my medications except prednisone and any other anti-inflammatory medication Advil, Tylenol, etc. Hydroxychloroquine Plaquenil is considered a disease-modifying anti-rheumatic drug DMARD. It can decrease the pain and swelling of arthritis. It may prevent joint damage and reduce the risk of long-term disability. Hydroxychloroquine is in a class of medications that was first used to prevent and treat malaria. Feb 21, 2018 Plaquenil has been used as an "off-label" treatment -- meaning it's approved for uses other than to treat osteoarthritic hand pain -- but there's been little evidence about its effectiveness.