Pattern of Retinopathy: Although the locus of toxic damage is parafoveal in many eyes, Asian patients often show an extramacular pattern of damage. Dose: We recommend a maximum daily HCQ use of 5.0 mg/kg real weight, which correlates better with risk than ideal weight. Hydroxychloroquine 100 mg tablets Chloroquine diphosphate mechanism of action Icd 9 code for plaquenil retinopathy HCQ is cleared by the kidneys and thus renal disease increases the risk of toxicity. Therefore, both dosage and screening frequency may need to be adjusted. Tamoxifen use used in breast cancer treatment increases the risk of toxicity approximately 5 fold 8. The mechanism of this linkage is not understood. Hydroxychloroquine Plaquenil is considered a disease-modifying anti-rheumatic drug DMARD. It can decrease the pain and swelling of arthritis. It may prevent joint damage and reduce the risk of long-term disability. Hydroxychloroquine is in a class of medications that was first used to prevent and treat malaria. I have been on hydroxychloroquine Plaquenil for 13 years and I go to my Eye Dr. for my annual visual field exam. Well I get bad news, I now have what he claims to be poison in one of the eyes. Risk of Toxicity: The risk of toxicity is dependent on daily dose and duration of use. There are no similar demographic data for CQ, but dose comparisons in older literature suggest using 2.3 mg/kg real weight. Eye exam for plaquenil use Plaquenil Uses, Dosage & Side Effects -, Hydroxychloroquine Plaquenil Other alternatives to hydroxychloroquine for lupusProguanil plus chloroquineOct en face retina mesaurements plaquenilChloroquine alcohol interaction Risk factors for retinopathy included higher doses and longer durations of use. Other major factors are concomitant renal disease, use of tamoxifen and prior retinal or macular disease. Thus, the new AAO screening and follow-up recommendations are shown below. My Take on New Ocular Screening Guidelines for Plaquenil.. Plaquenil oral Reviews and User Ratings Effectiveness, Ease.. Hydroxychloroquine toxicity - EyeWiki. All the tests will be assessed by an ophthalmologist hospital eye doctor after you have left the clinic. A report will be sent to you, your GP and/or the hospital doctor who prescribed hydroxychloroquine. No signs of retinopathy. If all the tests show a normal retina then there are no signs of retinopathy. Hydroxychloroquine Plaquenil was originally used to treat malaria and is now used mostly to treat rheumatological and dermatological diseases. Its most frequent use now is for Rheumatoid Arthritis RA and Lupus and is often very effective in mitigating the joint and arthritic symptoms these diseases can cause. Plaquenil is the brand name for the prescription drug hydroxychloroquine. It's used to treat and prevent malaria infection, and to reduce symptoms and progression of autoimmune diseases such as lupus, rheumatoid arthritis, and others.