In Sjögren’s, Plaquenil is used to treat many symptoms of Sjögren’s including fatigue, joint symptoms of arthritis and arthralgias (joint pain), dry mouth and dry eyes. Similar to its use in systemic lupus erythematosus, many clinicians feel that it is useful in reducing general Sjögren’s “disease activity.” One of the reasons that physicians feel comfortable in prescribing Plaquenil is its low risk to benefit ratio. Plaquenil and intestinal problems Plaquenil warnings Chloroquine working concentration How does plaquenil work for arthritis Hydroxychloroquine belongs to a group of medicines known as antimalarials. It works by preventing or treating malaria, a red blood cell infection transmitted by the bite of a mosquito. However, this medicine is not used to treat severe or complicated malaria. Nov 09, 2018 Taking hydroxychloroquine long-term or at high doses may cause irreversible damage to the retina of your eye. Stop taking hydroxychloroquine and call your doctor at once if you have trouble. Macular toxicity is related to the total cumulative dose rather than the daily dose. Regular eye screening, even in the absence of visual symptoms, is recommended to begin when either of these risk factors occurs. Toxicity from hydroxychloroquine may be seen in two distinct areas of the eye the cornea and the macula. As with any medication, allergic reactions including skin rashes and non-allergic reactions can occur. This means that the side effects of Plaquenil are mild and infrequent compared with its potential benefits. Hydroxychloroquine eye symptoms Hydroxychloroquine-Induced Retinal Toxicity - American., Hydroxychloroquine - Side Effects, Dosage, Interactions. Can plaquenil cause a rash Hydroxychloroquine and chloroquine work in a similar way as antimalarial medication with different therapeutic and toxic doses and produce a similar pattern of retinopathy. HCQ appears to be considerably less toxic to the retina than CQ, possibly because chloroquine passes the blood – retinal barrier easier. Symptoms Retinal toxicity associated with chronic exposure to.. Hydroxychloroquine - Wikipedia. Post-exposure Prophylaxis for SARS-Coronavirus-2 - Full.. Diagnosis Hydroxychloroquine-induced retinal toxicity Discussion. Chloroquine CQ and hydroxychloroquine Plaquenil HCQ have been used for many years, initially for the treatment of malaria but now more commonly for the treatment of inflammatory diseases such as rheumatoid arthritis and lupus 1. Since then my arthritis has gotten worse i have AS not RA so bad I couldn't walk and desperately needed something. Sooo, i restarted the plaquenil three weeks ago and of course again I got eye pain more in the left but I kept at it since the eye docs said eye pain is not a sign of retinal toxicity since there are no sensory receptors there. A 57-year-old female presented to the Ophthalmology clinic at UIHC complaining bilateral central photopsias for the past two years. She suffered from Sjogren syndrome and inflammatory arthritis and was currently treated with prednisone and methotrexate. She was previously treated with hydroxychloroquine Plaquenil 200mg bid 6.5mg/kg for 10 years, which was stopped one year prior to.