It typically happens in the evening or nighttime hours when you're sitting or lying down. Restless legs syndrome, also known as Willis-Ekbom disease, can begin at any age and generally worsens as you age. It can disrupt sleep, which interferes with daily activities. Chloroquine mitochondria Rheumatoid arthritis treatment plaquenil mono After about 4 day of being off Plaquenil I quickly realized that it in deed was helping. I was at work and at the end of my day I proceeded to walk to my car and could barley raise my legs to walk. I legs felt so heavy, the fatigue was at an all time high and the joint and muscle pain was unbearable. I am also suffering from RA and fibromyalgia. My legs and arms also feel very heavy and numb at times. I try to accomplish one goal a day, and maybe more if I can. I am taking Humira and Plaquenil for the RA and Lyrica for the fibromyalgia. They seem to help, but of course I have good days and bad days. Have any of you considered Lyme disease. The heavy arms and legs are a symptom of that also. Many people with lyme have been misdiagnosed with lupus and fibro and MS and many other things. I am just throwing it out there. I was just about to go on the Lyme board and saw the title "heavy arms and legs" it caught my eye. I have that symptom as. Medications also help many people with symptoms as abnormal, unpleasant sensations in their legs or feet. They do, however, consistently describe the desire to move their legs. Sometimes, symptoms disappear for periods of time, then come back. Simple self-care steps and lifestyle changes may help relieve symptoms. The sensations, which generally occur within the limb rather than on the skin, are described as: usually don't describe the condition as a muscle cramp or numbness. Plaquenil heavy legs Burning Feet Syndrome Grierson-Gopalan Syndrome, Arm and leg heaviness" Rheumatoid Arthritis Community. Chloroquine phosphate and primeIs plaquenil safe to take while breastfeedingWhich is more effective methotrexate or plaquenilPlaquenil 200 mg film-coated tablets This was twice cleared up with heavy doses of antibiotics and Cortisone. However my rheumatologist took me off all arthritis drugs and we added them back little by little. When plaquenil was finally included with the other drugs again, it took about three days and my My face started swelling and the rash and and itching. Plaquenil User Reviews for Rheumatoid Arthritis at. Heavy Legs & Arms -. Hydroxychloroquine Uses, Dosage & Side Effects -. I have been on 400 mg daily of Plaquenil, last week my doctor took me off of it ue to increase in the pain I had been having in lower back and unbelievable pain in my left leg and especially the extreme pain in the heel of my left foot. It was becoming painful to walk. After 5 days of stopping pain was 80% better. I too have that 'heavy' feeling in my legs where it feels almost as if you won't be able to pick up your feet and so tend to shuffle. Going up steps is very difficult as some days it is easier to move one leg than the other. I don't, however, have to be standing a lot for this to happen. Note This document contains side effect information about hydroxychloroquine. Some of the dosage forms listed on this page may not apply to the brand name Plaquenil. For the Consumer. Applies to hydroxychloroquine oral tablet. Along with its needed effects, hydroxychloroquine the active ingredient contained in Plaquenil may cause some unwanted effects.