But Chloroquine has significantly higher rate of retinal toxicity, so it isn't used much anymore. Also, Plaquenil appears to effectively reduce flares in patients with lupus not necessarily by suppressing immunity. Read more Anxiety over potential eye problems with Hydroxychloroquine is completely unwarranted if the dose is kept below 6mg/kg (2.2lbs) of body weight. Read more See 1 more doctor answer It can cause eye problems so you need to see an ophthalmologist and peridoic screenings. Read more Results are very good, particulary when used alone and better with methotrexate. Pct and hydroxychloroquine mechanism Plaquenil and face rash Also, Plaquenil appears to effectively reduce flares in patients with lupus not necessarily by suppressing immunity. So other meds like Imuran and CellCept mycophenolate mofetil also reduce flares, but also increases infection. My rheumy has just prescribed Plaquenil for my SS. Reading the warnings, I see that there is concern about effects on the eyes retinas. I am very concerned about this and am wondering if anyone out there has been put on an alternative drug to treat their SS. I have several issues with my. Here are the three most common antimalarial drugs prescribed for lupus Hydroxychloroquine Plaquenil This is the most commonly prescribed antimalarial. Chloroquine Aralen This drug has been known to have more serious side effects. Quinacrine Atabrine Quinacrine is another. Chloroquine can be substituted for Plaquenil but only in limited circumstances. Please provide more detailed information if you want a more specific answer. Read more See 1 more doctor answer Depends on what you are being treated for.... Read more While plaquenyl is a slow acting but effective drug, Prednisone is used in much higher doses in active sle. Arthritis (non-deforming) or arthralgias associated with the disease will have substantial pain relief with a dose this low. It's infusion intervals are longer, because the turnover of recptors is slower than the production of tnf-a itself. So other meds like Imuran and Cell Cept (mycophenolate mofetil) also reduce flares, but also increases infection. Read more It depends why you are taking Plaquenil in the first place. Apart from some stomach quiziies, I have never stopped this drug, as long as it demonstrated it is working. Other than that we see a few people who have increased skin pigmentation called "plaquenil ochronosis". The dirrence with Remicade (infliximab) is that it blocks the tnf-a receptor, rather than binding tnf-a itself, but it accomplishes the same thing. Lupus alternatives to plaquenil Plaquenil Shortage Leaves RA, Lupus Patients in Pain and., Alternatives to Plaquenil DailyStrength Chloroquine phosphate for ichSensorineural hearing loss and plaquenilChloroquine slidesharePlaquenil dosage lyme I am so afraid to take plaquenil for lupus treatment! any natural cure? Does anyone has an experience with plaquenil? or some one knows a natural way to cure lupus? I am currently taking oil fish, cellfood and recovery for joint pain and multi-vitamins. I am so afraid to take plaquenil for lupus treatment! any.. Plaquenil What You Need to Know - Kaleidoscope Fighting Lupus. Discontinuing Plaquenil. any other options?. I originally took Plaquenil Sanofi but this brand is now discontinued. The generic form of this, on my prescription, gives me serious digestion and stomach upsets to a point I spent months trying to figure out what I thought was irritable bowel syndrome. Has anyone found a good alternative UK brand that doesn't create this side affect. The alternative to Plaquenil is a slightly different anti malarial called Quinacrine. Plaquenil replaced Quinacrine formerly called Atabrine for anti malarial prophylaxis so now the Quinacrine has to be made up into pills or gel capsules by a compounding pharmacy. Potential side effects of anti-malarial drugs include Skin rashes and pigment change. Atabrine, specifically, can cause yellow pigmentation of skin. Sometimes Plaquenil can also deposit in the tissues. Dry skin. Loss of appetite. Abdominal bloating. Upset stomach. Stomach cramps. Retinal damage.