Why is p falciparum resistance to chloroquine

Discussion in 'Generic Chloroquine Online' started by Mustafallah, 03-Mar-2020.

  1. LAleksss Well-Known Member

    Why is p falciparum resistance to chloroquine


    Chloroquine was first discovered in the 1930s in Germany and began to be widely used as an anti-malaria post-World War II, in the late 1940s. However, resistance to the drug also rapidly emerged, with the first cases of not being cured by administration of chloroquine being reported in the 1950s.

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    The P. falciparum chloroquine-resistance transporter PfCRT In 2000 a report by David Fidock and colleagues associated chloroquine resistance with mutations to the gene for a digestive vacuole transmembrane protein, pfcrt. PfCRT is a member of the drug/metabolite transporter superfamily. Plasmodium falciparum chloroquine resistance is a major cause of worldwide increases in malaria mortality and morbidity. Recent laboratory and clinical studies have associated chloroquine resistance with point mutations in the gene pfcrt. However, direct proof of a causal relationship has remained elusive and most models have posited a. Malaria caused by Plasmodium falciparum is a severe infectious disease with high mortality and morbidity rates worldwide. Chloroquine CQ is a widely used antimalarial agent, but the emergence and spread of CQ-resistant parasites is a growing global.

    Nowadays, other drugs, and notably ones containing artemisinin-based compounds, are preferentially used to treat uncomplicated malaria and especially in areas where chloroquine resistance is known to occur. Since then, resistance has spread rapidly (since obviously it is beneficial to the parasite to be resistant, so various mutations conferring this protection have arisen multiple times in different areas in the world and also been passed on preferentially to new generations of malaria parasites), and now chloroquine resistant are found in multiple locations in south-east Asia, such as Myanmar and India, as well as from Guyana in South America.

    Why is p falciparum resistance to chloroquine

    Chloroquine Resistance in Malaria - ResearchGate, Chloroquine Resistance in Plasmodium falciparum Malaria.

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  5. Revised Recommendations for Preventing Malaria in Travelers to Areas with Chloroquine-Resistant Plasmodium falciparum. Since 1982, CDC has recommended the combined use of chloroquine and Fansidar pyrimethamine-sulfadoxine as the primary chemoprophylactic regimen for travelers to areas with transmission of chloroquine-resistant Plasmodium falciparum CRPF.

    • Revised Recommendations for Preventing Malaria in..
    • Plasmodium falciparum chloroquine resistance transporter is a..
    • Return of Chloroquine Antimalarial Efficacy in Malawi NEJM.

    Chloroquine was first discovered in the 1930s in Germany and began to be widely used as an anti-malaria post-World War II, in the late 1940s. However, resistance to the drug also rapidly emerged, with the first cases of Plasmodium falciparum not being cured by administration of chloroquine being reported in the 1950s. Extrusion of chloroquine CQ from digestive vacuoles through the Plasmodium falciparum CQ resistance transporter PfCRT is essential to establish CQ resistance of the malaria parasite. However, the physiological relevance of PfCRT and how CQ-resistant PfCRT gains the ability to transport CQ remain unknown. These reports of chloroquine-prophylaxis or treatment failures were substantiated by serial parasitologic and clinical observations of each infection and, when available, in-vitro confirmation of drug resistance. CDC continues to monitor the status of chloroquine-resistant P. falciparum malaria in East Africa 2.

     
  6. yana11 Moderator

    Chloroquine is a lysosomotropic agent that prevents endosomal acidification [1]. The effect of pH on the uptake and toxicity of the bivalent. - Wiley Chloroquine - FDA prescribing information, side effects. Pharmacokinetics of Chloroquine and Monodesethylchloroquine.
     
  7. skyvip New Member

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