Hydroxychloroquine induced cardiomyopathy and heart failure in twins

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    Hydroxychloroquine induced cardiomyopathy and heart failure in twins

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    INTRODUCTION Hydroxychloroquine-induced cardiomyopathy is a rare and life-threatening condition characterized by restrictive hemodynamics. Drug cessation and aggressive afterload reduction halts disease allowing for clinical recovery. We present a 50-year-old woman with hydroxychloroquine-induced restrictive cardiomyopathy and correlate clinical, echocardiographic, and right heart. Hydroxychloroquine HCQ is a commonly used drug that has been linked to drug-induced cardiomyopathy. A 57 year old female with a history of systemic lupus erythematosus stable on HCQ for 30 years and known MYBPC3 gene positive hypertrophic cardiomyopathy HCM presented with decompensated heart Is a platform for academics to share research papers.

    For example, it may be combined with an antibiotic to treat chronic Q-fever, which humans usually catch from farm animals or raw milk. Plaquenil is used to treat other types of infections too.

    Hydroxychloroquine induced cardiomyopathy and heart failure in twins

    Heart Failure/Cardiomyopathy Boston Medical Center, HYDROXYCHLOROQUINE CARDIOMYOPATHY IN A PATIENT WITH GENE.

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  4. Hydroxychloroquine-induced cardiomyopathy and heart failure in twins. Zhao H12, Wald J1, Palmer M3, Han Y1. Author information 1Cardiovascular Division, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.

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    We present a case of twin sisters who both suffered from systemic lupus erythematosus SLE and HCQ-induced cardiomyopathy presenting with decompensated heart failure HF, suggesting that genetic predisposition might be a factor in HCQ-induced cardiomyopathy. Clinical manifestations of antimalarial-induced cardiotoxicity can manifest as restrictive cardiomyopathy, dilated cardiomyopathy, or conduction abnormalities such as bundle branch and atrioventricular block. Patients usually present with HF symptoms. However, non-specific chest discomfort may be a presenting or coexisting feature. Systemic lupus erythematosus SLE is a chronic autoimmune disorder that manifests with multiorgan inflammation. Cardiac involvement is common, with manifestation that include pericarditis, myocarditis, conduction defects, valvular disease, and coronary artery disease. In addition to cardiac disease in adults with SLE, the children of women with SLE can develop neonatal lupus by passive.

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