However, it can interact with some common medications, altering their effects on your body. If you’re curious about the grapefruit warning on many medicines, this article will help you understand why it’s there and what your options are. Chloroquine phosphate and invertebrates Plaquenil for fatigue Hydroxychloroquine nursing implications Screening criteria for ocular toxicity of plaquenil Negative Effects of CBD drug Interactions. Although there is still limited research on the subject, it’s possible that too much CBD could trigger toxic levels of certain drugs in the bloodstream. Certain anticoagulant drugs also use the P450 metabolic pathway, and when taken with CBD, increased serum levels could prove fatal. Along with its needed effects, hydroxychloroquine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur while taking hydroxychloroquine Incidence not known Safe use of this drug in the treatment of juvenile rheumatoid arthritis has not been established.-Retinopathy has been reported to be higher when the maintenance dose is exceeded.-Should a relapse occur after medication is withdrawn, therapy may be resumed or continued on an intermittent schedule if there are no ocular contraindications. Medications are processed in your liver and small intestine by a specialized group of proteins called cytochrome P450 (CYPs). Here’s a closer look at 32 common drugs that may have dangerous interactions with grapefruit. Hydroxychloroquine not to mix with medication Do Not Eat Grapefruit With Any of These 32 Common Drugs., Hydroxychloroquine Side Effects Common, Severe, Long Term - Can you take doxycycline with plaquenil Hydroxychloroquine may cause some people to be agitated, irritable, or display other abnormal behaviors. It may also cause some people to have suicidal thoughts and tendencies, or to become more depressed. If you or your caregiver notice any of these side effects, tell your doctor right away. This medicine may cause hypoglycemia low blood sugar. Hydroxychloroquine Oral Route Precautions - Mayo Clinic. Hydroxychloroquine Dosage Guide with Precautions -. Hydroxychloroquine Oral Interactions with Other Medication. Provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Hydroxychloroquine may also be used for purposes not listed in this medication guide. Taking hydroxychloroquine long-term or at high doses may cause irreversible damage to the retina of your eye. This list does not include all of the potential medications impacted by cannabidiol. Nor will every medication in the categories contained on this list will cause an interaction. For these reasons, you should consult with a medical professional before supplementing with CBD oil.