Plaquenil is used to treat or prevent malaria, a disease caused by parasites that enter the body through the bite of a mosquito. Malaria is common in areas such as Africa, South America, and Southern Asia. Chloroquine overdose treatment Is plaquenil an antimalarial drug I am very underweight and do have chronic diarrhea, but gosh, this seems invasive as a first step in trying to figure out why. Has anyone had chronic diarrhea/weight loss from Plaquenil? I know it can be a temporary side effect for some, but I've been on it for a year. Summary Diarrhea is found among people who take Plaquenil, especially for people who are female, 60+ old, have been taking the drug for 1 - 6 months, also take medication Enbrel, and have Pain. This study is created by eHealthMe based on reports of 48,911 people who have side effects when taking Plaquenil from Food and Drug Administration FDA. Side effects are nausea and diarrhea, which often improve with time. Less common side effects include rash, changes in skin pigment such as darkening or dark spots, hair changes, and muscle weakness. Rarely, hydroxychloroquine can lead to anemia in some individuals. This can happen in individuals with Plaquenil is also an antirheumatic medicine and is used to treat symptoms of rheumatoid arthritis and discoid or systemic lupus erythematosus. This medicine is not effective against all strains of malaria. Plaquenil diarrhea nausea Hydroxychloroquine Plaquenil, Will you have Diarrhea with Plaquenil - eHealthMe Chloroquine transfectionHydroxychloroquine and methotrexate interaction RARE side effects. If experienced, these tend to have a Severe expression. Abnormal Liver Function Tests. Acute Liver Failure. Acute Pustular Eruptions On Skin. Bronchospasm. Decreased Blood Platelets. Decreased White Blood Cells. Common and Rare Side Effects for Plaquenil Oral. PATIENT FACT SHEET Hydroxychloroquine Plaquenil. Plaquenil = explosive diarrhea -. Plaquenil is generally well-tolerated, but side effects are possible. Common side effects linked to Plaquenil include nausea and diarrhea. Taking the medication with food eases nausea for most people taking the drug. Less common side effects include skin rashes, hair thinning, and weakness. I’ve been on plaquenil for almost 3 years and I still have diarrhea and to a lesser extent heartburn and nausea sometimes. The first year or two I was on plaquenil I didn’t have a normal bowel movement for as long as I could remember and was constantly nauseous and could barely eat. Apr 21, 2017 I had severe nausea and diarrhea when started on Plaquenil 2 X 200mg tabs once daily almost 3yrs ago. As I also have Crohn's Disease and an Ileostomy this was putting me at serious risk. I was told to stop the Plaquenil until my GI symptoms disappeared.