It regulates the activity of the immune system, which may be overactive in some conditions. Hydroxychloroquine can modify the underlying disease process, rather than simply treating the symptoms. Images early plaquenil toxicity fundus autoflurouecense Plaquenil plm Plaquenil kidney damage The usual starting dose of Plaquenil is 200 mg twice a day or 400 mg once a day, administered orally, in people weighing 80 kg or more. The usual dosage works for most people who take Plaquenil, but it is possible to increase or decrease the dose based on individual needs. It's important to watch for possible side effects and toxicity. Plaquenil takes quite a long time to get to its peak effectiveness depending on what you read, anywhere from 3 months to a year. Unless you are having significant side effects, try to give it at least 6 months before you decide it doesn't work for you. How long until Plaquenil started working? Support Forums. It's pretty suttle. One day all the sudden you will notice that your arms or legs or feet don't feel as bad as they used to. Not that it is a cure all but it usually does help. It kind of reminds me of a vitamin. You don't notice it's working until you stop taking it. Hydroxychloroquine is often taken in combination with other drugs such as methotrexate. Over the long term hydroxychloroquine can reduce pain, swelling and joint stiffness. It may be as long as 12 weeks before you notice the benefits. Days plaquenil to work Hydroxychloroquine Oral Uses, Side Effects, Interactions., PLAQUENIL" Rheumatoid Arthritis Community - Support Group How to treat plaquenil rashPrecio plaquenil cvsPlaquenil side effects go awayPictures of plaquenil rash The Plaquenil is supposed to kick in in 3 to 6 months. I think it was 8 months for me. One day I was congratulating myself for getting so many things done and I realised that the days had been getting better without my noticing. In the beginning I also was on a low dose of prednisone, which helped until plaquenil kicked in. How long did Plaquenil/Hydroxychloroquine take? DailyStrength. How long until Plaquenil started working?. Hydroxychloroquine Side-effects, uses, time to work. Hydroxychloroquine comes in an oral tablet. Adult dosing ranges from 200 mg or 400 mg per day 6.5mg/kg. In some cases, higher doses can be used. It is recommended one tablet twice daily if taking more than one tablet. It is recommended to be taken with food. Your doctor may adjust your dose if needed. However, dose is usually not more than 600 mg or 6.5 mg per kilogram kg of body weight per day, whichever is lower. Children—Use and dose must be determined by your doctor. For treatment of lupus Adults—200 to 400 milligrams mg taken as a single dose or in two divided doses once a day. My question is for those that have taken Plaquenil/Hydroxychloroquine. How long did it take for it to remove symptoms in your personal experience? I know I've read it can take up to 6 months but what I'm wondering is, do you just wake up one day and find it's kicked in 6 months down the road or more likely, it starts to work slowly over 6 months?