We aimed to compare the efficacy and safety of HCQ and corticosteroid treatment in patients with Ig AN. Ninety-two patients with Ig AN who received HCQ in addition to routine renin-angiotensin-aldosterone system inhibitors (RAASi) therapy were included. Ninety-two matched historical controls who received corticosteroids were selected by propensity score matching. Baseline proteinuria levels were comparable between the HCQ and corticosteroid groups (1.7 [1.2, 2.3] vs. The percentage reduction in proteinuria at 6 months was smaller in the HCQ group than in the corticosteroid group (− 48.5% [− 62.6, − 31.4] vs. The time averaged proteinuria within the 6 months of observation was comparable for the HCQ and corticosteroid groups (1.1 [0.8, 1.5] vs. The cumulative frequency of patients with a 50% reduction in proteinuria during the study was also comparable between the two groups (52.2% vs. However, six of the 92 (6.5%) patients suffered from severe adverse events (SAEs) in the corticosteroid group, while no SAEs were observed in the HCQ group (6.5% vs. The antiproteinuric effect of HCQ might be slightly inferior to that of corticosteroids over 6 months in patients with Ig AN who were deemed to be candidates for HCQ and not corticosteroids treatment. Alternative for plaquenil Chloroquine and itching Antacid and plaquenil Plaquenil is an arthritis medication and an anti infectious agent. Prednisone is a steroid. There may be a negative interaction between Plaquenil and alcohol. There may be a negative interaction between Prednisone and alcohol. Plaquenil - Better Than Prednisone? The conclusion is that I have an autoimmune disease that has affected my kidneys. Throughout the 12 1/2 years, I have been prescribed 10mg of predinsone a day during my `worst' time to 1 mg every other day when I was in `serious' remission. Prednisone is a corticosteroid, a type of medication that's very effective in managing inflammation in rheumatoid arthritis and many other conditions. Unfortunately, corticosteroids also can dramatically weaken bones and lead to osteoporosis. To protect your bones, do weight-bearing exercise, avoid alcohol and don't smoke. Ig A nephropathy (Ig AN) is the most prevalent type of primary glomerulonephritis worldwide . However, HCQ treatment was safer than corticosteroid treatment. Corticosteroids vs plaquenil Treating Lupus with Anti-Malarial Drugs Johns Hopkins Lupus., Immune & Autoimmune - Lupus Plaquenil - Better Than. Can i take claritin with plaquenilHydroxychloroquine accutane rednessPlaquenil malaria mechanismHydroxychloroquine street value The antiproteinuric effect of HCQ might be slightly inferior to that of corticosteroids over 6 months in patients with IgAN who were deemed to be candidates for HCQ and not corticosteroids treatment. However, HCQ treatment was safer than corticosteroid treatment. Comparison of the effects of hydroxychloroquine and.. Osteoporosis and long-term prednisone What is the risk? - Mayo Clinic. Steroids Overview Corticosteroids vs Anabolic Steroids, Side.. While side effects of corticosteroids are usually to blame, there is also the possibility of ocular damage associated with long-term use of the antimalarial drugs hydroxychloroquine brand name Plaquenil® and chloroquine. Improved vision screening tests and updated dosing guidelines are key to avoiding such complications. Apr 09, 2008 This guide summarizes evidence comparing the effectiveness and safety of disease-modifying antirheumatic drugs DMARDs and corticosteroids used for rheumatoid arthritis RA. It does not address other drugs that are no longer commonly used as first-line treatment for RA, such as azathioprine, chloroquine, cyclosporine, gold, and penicillamine. Jun 09, 2006 Key words Rheumatoid arthritis, perioperative management, corticosteroids, methotrexate, anti-TNF, rituximab Introduction Rheumatoid arthritis RA, the most common form of inflammatory arthritis, can lead to significant pain, disability, and deformity, and is a multisystem autoimmune disorder.