Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur while taking hydroxychloroquine: Incidence not known Some side effects of hydroxychloroquine may occur that usually do not need medical attention. What are some side effects of hydroxychloroquine Chloroquine resistant malaria areas Chloroquine maculopathy Chloroquine endosomal acidification inhibitor Side effects are uncommon; however, a few people may develop a rash, indigestion, diarrhoea, headache, blurred vision, darkening of the skin, or bleaching of the hair. Hydroxychloroquine can aggravate pre-existing psoriasis. Hydroxychloroquine Plaquenil is a drug that is classified as an anti-malarial drug. Plaquenil is prescribed for the treatment or prevention of malaria. It is also prescribed for the treatment of rheumatoid arthritis, lupus, and the side effects of lupus such as hair loss, joint pain, and more. Jan 11, 2012 I have been on the plaquenil 200 mgm for about 4 months now. I did stop it for 2 weeks early in the treatment due to having to take a coupld other drugs that seemed to give me side effects. I just quit the plaquenil to give my liver a rest at that time. Noticed nothing different. Plaquenil isn a antiparasitic drug with anti-inflammatory affect. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. These side effects may go away during treatment as your body adjusts to the medicine. Bad side effects of plaquenil Plaquenil Indications, Side Effects, Warnings -, Hydroxychloroquine Plaquenil Side Effects & Dosage for Malaria Hydroxychloroquine gingival hyperplasia Common side effects may include headache, dizziness, ringing in your ears; nausea, vomiting, stomach pain; loss of appetite, weight loss; mood changes, feeling nervous or irritable; skin rash or itching; or. hair loss. Side Effects of Plaquenil Hydroxychloroquine, Warnings, Uses. Let me tell you what weaning down from Plaquenil is like.. The Risk of Retinal Toxicity with Plaquenil. RARE side effects. If experienced, these tend to have a Severe expression. Abnormal Liver Function Tests. Acute Liver Failure. Acute Pustular Eruptions On Skin. Bronchospasm. Decreased Blood Platelets. Decreased White Blood Cells. And plaquenil does miracle for pain. Try to not remove it from your treatment plan. I had this med removed for 2 years and suffered quite a lot of joint, muscle and tendon pain. The main side effect from plaquenil is some digestive problems. Severe is retinal degradation, everyone should get an eyefield test yearly. Plaquenil is the devil! Worked well 1st 2 mts. After that I had issues with my vision, felt waves of nervousness, and extreme anxiety where I started to question my sanity. Hallucinated, broke out in rashes and crying spells.