Chloroquine blood to plasma ratio

Discussion in 'Plaquenil' started by dimaqq, 18-Mar-2020.

  1. Muzin70 Well-Known Member

    Chloroquine blood to plasma ratio


    Knowing a drug’s potential for partitioning is critical in situations where the test drug has a high Log P (lipophilic). In this situation a significant portion of the drug may be taken up and held by red blood cells (RBCs).

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    Oct 25, 2012 The drug is extensively distributed, with a volume of distribution of 200 to 800 L/kg when calculated from plasma concentrations and 200 L/kg when estimated from whole blood data concentrations being 5 to 10 times higher. Chloroquine is 60% bound to plasma proteins and equally cleared by the kidney and liver. Blood from the volunteers was incubated with varying concentrations of chloroquine CQ, desethylchloroquine DCQ and bisdesethyl-chloroquine BDCQ for 15 min and the RBC/plasma concentration ratio determined. Desethylchloroquine and BDCQ were concentrated in the red cells of uninfected blood to the same extent as chloroquine. The packed cell volume PVC of the test blood is determined. Once the blood-drug dilutions are made the samples are incubated for 24 hours at 37°C. After incubation, plasma and RBCs are separated by centrifugation of whole blood samples at 1200 rpm for 10 minutes.

    When the combined knowledge of protein binding and blood partitioning is understood investigators can make a better determination about whether they should collect whole blood, plasma, or serum for assaying pharmacokinetic behavior of the drug if animal or clinical ADME studies. For this reason, more informative data describing drug distribution in blood can be obtained by determining both the blood partitioning ratios and direct protein binding.

    Chloroquine blood to plasma ratio

    Pharmacokinetics of chloroquine in Thais plasma and red., Comparison of the partitioning in vitro of chloroquine and.

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  5. From the saliva plasma relationship, the extent of chloroquine binding to plasma proteins was estimated to be 47%. The C max and AUC 0–6 day values obtained from saliva data was about half those from plasma, while the T max obtained from both fluids remained the same.

    • Pharmacokinetics of chloroquine Saliva and plasma levels..
    • Protein Binding and Blood To Plasma Ratio Cell Partitioning..
    • Chloroquine - FDA prescribing information, side effects and uses.

    Verapamil, chloroquine Figure 1 and 2 Detection method LC-MS/MS with internal standard Results blood to plasma ratio Figure 1. Blood to plasma ratio obtained for two reference compounds in 3 different species Figure 2. Comparison of in-house human blood to plasma ratio with literature values 1,2 1 Obach 1999, Drug Metab Dispos 27, 1350 The Blood-To-Plasma Ratio and Protein binding assays provide our clients with important information that describes how their test molecule interacts with whole blood and plasma proteins. Knowing a drug’s potential for partitioning is critical in situations where the test drug has a high LogP lipophilic. Chloroquine is rapidly and almost completely absorbed from the gastrointestinal tract, and only a small proportion of the administered dose is found in the stools. Approximately 55% of the drug inthe plasma is bound to nondiffusible plasma constituents. Excretion of Chloroquine is quite slow,but is increased by acidification of the urine.

     
  6. osv Well-Known Member

    Summary Chloroquine is an anti-malarial drug available at pharmacies for people traveling to area with malaria risks. What Conditions does Plaquenil Treat? - WebMD Will you have Mouth ulcers with Plaquenil - eHealthMe Hydroxychloroquine Side Effects, Dosage, Uses, and More
     
  7. cheafa XenForo Moderator

    500 mg chloroquine phosphate (300 mg base) orally on the same day each week Comments: -If possible, suppressive therapy should start 2 weeks prior to exposure; if unable to start 2 weeks before exposure, an initial loading dose of 1 g chloroquine phosphate (600 mg base) may be taken orally in 2 divided doses, 6 hours apart. Chloroquine — Wikipedia Republished // WIKI 2 Coronavirus disease 2019 - Wikipedia Chloroquine retinopathy - Wikipedia
     
  8. AndrewRock New Member

    Plaquenil side effects - kidney problems? - Symptoms - Life. Aug 26, 2016 I was getting diarrhea after staring plaquenil. My Gastro dr gave me VSL-3, its a probiotic. It is like a miracle drug to me. I haven't had diarrhea in a year. Maybe you can try that. It's over-the-counter. The pharamacist has t get it, it has to be refrigerated. I recently had to take an antibiotic which has a side effect, for my, of diarrhea.

    Plaquenil/ Diarrhea - Autoimmune diseases - Inspire
     
  9. demon2006 Moderator

    Hydroxychloroquine Side Effects Common, Severe, Long Term. Applies to hydroxychloroquine oral tablet. Along with its needed effects, hydroxychloroquine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur while taking hydroxychloroquine

    PLAQUENIL HYDROXYCHLOROQUINE SULFATE, USP WARNING.