Pattern of Retinopathy: Although the locus of toxic damage is parafoveal in many eyes, Asian patients often show an extramacular pattern of damage. Dose: We recommend a maximum daily HCQ use of 5.0 mg/kg real weight, which correlates better with risk than ideal weight. What type of drug is plaquenil What happens if you quit taking plaquenil To detect chloroquine toxicity. Plaquenil toxicity first affects small areas of the retina between 5° and 15° from the fovea. Figures 2 and 3 show three patients at different stages of toxicity. Patient B shows a less severe stage of toxicity with small islands of retinal damage in the areas 5° to 15° from the fovea. CONCLUSION. The electroretinogram ERG. The global or full-field electroretinogram ERG is a mass electrical response of the retina to photic stimulation. The ERG is a test used worldwide to assess the status of the retina in eye diseases in human patients and in laboratory animals used as models of retinal disease. Chloroquine CQ and hydroxychloroquine Plaquenil HCQ have been used for many years, initially for the treatment of malaria but now more commonly for the treatment of inflammatory diseases such as rheumatoid arthritis and lupus 1. It is now considered for new disease applications in diabetes, heart disease and adjunct cancer therapies 2. Risk of Toxicity: The risk of toxicity is dependent on daily dose and duration of use. There are no similar demographic data for CQ, but dose comparisons in older literature suggest using 2.3 mg/kg real weight. Plaquenil ff erg severe Expanded spectral domain-OCT findings in the early detection., The Electroretinogram and Electro-oculogram Clinical. Aralen online shoesHydroxychloroquine g6pd Dec 15, 2004 In late stages of the disease, full-field ERG may be nonrecordable even in the presence of a demonstrable field by kinetic perimetry. We have found recordable, though attenuated, multifocal ERG responses in patients with RP. The multifocal ERG is an objective method for following patients with extinguished full-field ERG See Figure 4. Multifocal ERG in Practice -. Hydroxychloroquine Plaquenil Toxicity and Recommendations.. Multimodal Imaging in Plaquenil Toxicity. Fatigue is found among people who take Plaquenil, especially for people who are female, 60+ old, have been taking the drug for 2 - 5 years, also take medication Enbrel, and have Pain. This study is created by eHealthMe based on reports of 48,911 people who have side effects when taking Plaquenil from Food and Drug Administration FDA, and is. Handheld SD-OCT revealed severe attenuation of the outer retina throughout the macula, but with preservation of outer retinal structures in the fovea. PMM2-CDG is a rare congenital disorder for which both ff-ERG and SD-OCT were useful in demonstrating early changes of retinal architecture and function. The electroretinogram ERG is a diagnostic test that measures the electrical activity generated by neural and non-neuronal cells in the retina in response to a light stimulus. The electrical response is a result of a retinal potential generated by light-induced changes in the flux of transretinal ions, primarily sodium and potassium.