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    3University of Illinois at Urbana-Champaign, Departments of Surgery (P. R.), College of Veterinary Medicine, Urbana, Illinois 618014Bioengineering (P. R.), College of Veterinary Medicine, Urbana, Illinois 618015Interdisciplinary Health Sciences Institute (P. R.), College of Veterinary Medicine, Urbana, Illinois 618016Division of Surgical Oncology (P. R.), College of Veterinary Medicine, Urbana, Illinois 6180110Onconostic Technologies Inc (S. ERα is targeted by endocrine therapies, which are generally well tolerated (1). The nuclear hormone estrogen receptor (ER)-α is present in approximately 75% of human breast cancers and is considered one of the most critical predictive factor of breast cancer prognosis (1). R.), Urbana, Illinois 61820 1Department of Food Science and Human Nutrition (K. The nuclear transport pathways have not previously been implicated in the development of endocrine resistance, and given the need for better strategies for selecting patients to receive endocrine modulatory reagents and improving therapy response of relapsed ERα( ) tumors, our findings show great promise for uncovering the role these pathways play in reducing cancer recurrences. In mechanistic studies we showed that the expression of . Using advanced statistical methods, we found that expression levels of several of nuclear transport genes including were associated with poor survival and predicted recurrence of tamoxifen-treated breast tumors in human breast cancer gene expression data sets. The objective of this study was to validate a group of nuclear transport genes as potential biomarkers to predict the risk of endocrine therapy failure and to evaluate the inhibition of , one of these genes as a novel means to enhance the effectiveness of endocrine therapies. M.-E.), College of Veterinary Medicine, Urbana, Illinois 618012Division of Nutritional Sciences (K. There is a critical need for therapeutic approaches that include novel, targetable mechanism-based strategies by which ERα ( ) tumors can be resensitized to endocrine therapies. How much benefit you get from tamoxifen for #malebreastcancer. zoloft drugs Tamoxifen drug Tamoxifen administration to mice - OpenWetWare
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