Chronic Superficial Keratitis (Pannus) is a disease seen most commonly in the German Shepherds, but does occur in other breeds. A progressive change occurs where blood vessels and scar tissue invade the cornea. This change usually begins in the temporal (outer) or ventral (lower) quadrant of the cornea, and severe cases can involve most or all of the corneal surface area resulting in blindness. With chronicity the affected areas become black with pigmentation. It is believed that Pannus is an immune mediated disease. That is, some subcellular change has occurred in the cornea which the immune system then recognizes as abnormal resulting in an immune mediated attack in the cornea almost as if the cornea was foreign or transplanted tissue. 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The topics are covered in the following order:1) What is distemper? - this section contains information about where and how animals can catch canine distemper; the high risk environments and whether distemper vaccines can cause disease. This section contains the following subsections: 4a) How do canine distemper viruses work (how do they replicate and destroy cells etc.) 4b) How does canine distemper affect the bone marrow, lymphatic tissues and blood cells? 11) Summary and take home messages - a summary of the important points. - this short section comprises a basic definition about what dog distemper is. 4c) How does canine distemper affect the intestine? 4g) How does canine distemper affect the eye and other organs? 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