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Calibrating Your Dosage Taking Zoloft Safely Combining Zoloft with Other Medical Therapies Community Q&A11 References When used properly, Zoloft can greatly improve the quality of life for people suffering from depression, anxiety, panic disorders, and other conditions. Zoloft, also known as sertraline, is a selective serotonin reuptake inhibitor (SSRI) drug. If you are currently taking Zoloft, work with both your primary doctor and your therapist to determine a dosage regimen that fits your needs. If you increase your dosage, do so slowly under your doctor’s supervision, and watch out for any possible side effects. Zoloft or sertraline hydrochloride is a medicament that mostly used to decrease such conditions like social disorder of anxiety, dejection, panic and other. This drug belongs to the type that has a name selective serotonin reuptake inhibitors or SSRIs. This action helps to calm down depression and other conditions. 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